Background
International evidence shows a strong association of air pollution exposure to increased risk of neurological disorders, and specifically Alzheimer’s disease. Fine particulate matter (PM) less than 2.5 micrometres in diameter (PM2.5) is especially dangerous due to its ability to penetrate into the respiratory system and bloodstream. PM2.5 constitutes a significant proportion of bushfire smoke. Climate change is increasing exposure with substantial health risks, including the entry of ultrafine particles into the brain. Vulnerable populations include frontline rural firefighters and ageing populations.
Approach
The student will work on data collected as part of our R-FIRE (Rural Firefighter Investigation of Risk & Exposure): Brain Health cohort study, in this data analysis project (dry lab). They will test for associations of long term PM2.5 exposure with general health outcome measures and comprehensive brain health measures (including Ecog HBA Functional Assessment tool, and our online cognitive testing battery assessing memory, reasoning, concentration, and planning).
Project Potential
The study aims to enable targeted screening and intervention efforts to mitigate the neurological consequences of smoke exposure, thereby improving health outcomes for affected individuals.