Background
Allergy is a major global health issue, especially in children, with no cure available. Allergy arises from defects in immune tolerance, our body's way of discerning microbiological friend from foe. We recently discovered a novel protein, AIP-2, which can restore immune tolerance and thus prevent the onset of allergy.
Aim
Our goal is to understand how AIP-2 achieve this, which would not only advance the field of immune tolerance but help to translate AIP-2 to the clinic.
Approach
In this project, students will help decipher the molecular mechanisms of AIP-2, using techniques in the following areas: cell culture, flow cytometry, molecular cell biology, metabolic biochemistry and/or systems biology (single cell / single nuclei RNAseq, Spatial transcriptomics) and modelling.
Project Potential
Experience with drug development and translation; work with human tissues, computational biology and modelling.