Research Focus
The Medical Genomics Team analyses next generation sequence data to address clinical challenges in a variety of diseases. The approaches we take include:
- Characterising cancer genomes with short and long read sequencing to diagnosis the genetic cause of disease
- Machine learning (ML) to predict patient outcomes and identify novel biomarkers
- Computational immunogenomics to identify cancer vaccine targets from genomic and transcriptomic data
- Bioinformatic approaches to understand tumour heterogeneity and the tumour micro-environment
- Identification of mutational processes that underlie tumour development
Ultimately, we aim to enable ‘personalised medicine’ for the diagnosis and treatment of cancer.
Gallery
Research Projects
Current Research Projects
Cancer Genomics
Integrated multi-omic analysis for machine learning to predict patient outcomes
Cancer Immunotherapy
Research Team
Miranda Vidgen
Bonnie Wong
Georgina Hollway
Rebecca Johnston
Funding
- National Health and Medical Research Council (NHMRC)
- Cancer Council Queensland
- Australian Cancer Research Foundation (ACRF)
- Cancer Australia
- Ian Potter Foundation
Publications
Addala V et al. Computational immunogenomic approaches to predict response to cancer immunotherapies. Nature Reviews Clinical Oncology. 2023 doi: 10.1038/s41571-023-00830-6. PMID: 37907723
Tran K et al. Performance of tumour microenvironment deconvolution methods in breast cancer using single-cell simulated bulk mixtures. Nature Communications. 2023 14(1):5758. doi: 10.1038/s41467-023-41385-5. PMID: 37717006
Naeini MN et al. Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy. Nature Communications. 2023 14(1):3155. doi: 10.1038/s41467-023-38891-x. PMID: 37258531
Student Projects
Further Information
- The Genome Variation and Regulation in Disease
- The Translational Cancer Immunotherapy Laboratory
- The Molecular Cancer Epidemiology Laboratory
- The Molecular Oncology Laboratory
- The Conjoint Gastroenterology Laboratory
- The Cancer Neuroscience Laboratory
- The Translational Oncology Discovery Group
- Sid Faithfull Brain Cancer Laboratory
- Andrew Barbour, Princess Alexandra Hospital and Frazer Institute, University of Queensland
- David Fielding, RBWH
- Peter Simpson, UQCCR, University of Queensland
- Sunil Lakhani and Amy McCart Reed, UQCCR, The University of Queensland
- Bruce Robinson, Jenette Creaney and Alec Redwood, NCARD and University of Western Australia
- Lata Vadlamudi, RBWH and UQCCR, University of Queensland
- James Wilmot, Melanoma Institute Australia
- Professor Kiarash Khosrotehrani, Frazer Institute, University of Queensland
- Aldo Scarpa, University of Verona
- Australian Genomics
- Pam Pollock, Queensland University of Technology
- Sean Grimmond, VCCC, University of Melbourne
- genomiQa Pty Ltd