The Cancer Genetic Susceptibility Laboratory

To identify prevention and therapeutic avenues for endometrial cancer

Associate Professor Tracy O’Mara

Team Head

The Cancer Genetic Susceptibility Laboratory - web graphic

Research Focus

The Cancer Genetic Susceptibility Laboratory primarily studies the role of genetics in endometrial cancer risk and development. Our team leads large-scale genetic studies for endometrial cancer and uses these data to answer a variety of research questions falling under three main themes: prevention, prediction and treatment.

Gallery

The Cancer Genetic Susceptibility Laboratory

Research Projects

Current Research Projects

Genome-wide association studies of endometrial cancer

Identification of causal risk factors or modifiable factors for cancer

Endometrial cancer risk prediction model development

Lab News

February 2026

Welcome to students Maya and Oak who will be completing their Honours projects in the Cancer Genetic Suseptibility Laboratory

Research Team

Associate Professor Dylan Glubb

Dr Nathan Ingold

Dr Preety Bajwa

Carly Chapman

Bianca Naumann

Funding

NHMRC
US Department of Defense
Worldwide Cancer Research
Cancer Australia
HRC New Zealand

Publications

O’Mara et al, Identification of nine new susceptibility loci for endometrial cancer. NatCommun. 2018. PMID: 30093612 https://pmc.ncbi.nlm.nih.gov/articles/PMC6085317/

Wang et al, Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels. iScience 2023. PMID: 37168552 https://pmc.ncbi.nlm.nih.gov/articles/PMC10165198/

Wang et al, 10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation. EBioMedicine, 2022. PMID: 35219087 https://pmc.ncbi.nlm.nih.gov/articles/PMC8881374/

See Google Scholar

Further Information

Internal Collaborations

The Molecular Cancer Epidemiology Laboratory

The Genome Variation and Regulation in Disease

The Cancer Metabolism Group

External Collaborations

ECAC collaborators (Endometrial Cancer Association Consortium) ecac-studies.org
BCAC consortium (Breast Cancer Association Consortium) http://apps.ccge.medschl.cam.ac.uk/consortia/bcac/
Dr Marc Gunter & Dr Laure Dossus, International Agency for Research on Cancer – World Health Organisation
Professor Emma Crosbie, University of Manchester
Associate Professor Caroline Ford, University of New South Wales
Associate Professor Logan Walker, University of Otago
Associate Professor Jason Gertz, Huntsman Cancer Institute
Professor Hugo Vankelecom, KU Leuven University

Resources

Past Clinical Trials/Studies