About
Dr Nayler studied Biochemistry and Biotechnology and has worked in the field of cell biology for over ten years. Dr Nayler obtained his PhD at the University of Queensland and has been involved with the study of rare neurological disease, including developing stem-cell based models of the immune and central nervous system. Dr Nayler is currently a post-doctoral researcher at QIMR-Berghofer, working alongside the Cardiac Drug Discovery lab, where he continues to apply informatics and systems methodology to combatting disease of the central nervous system.
Research Skills
- Stem cell culture
- Stem cell differentiation (Human brain organoids; cerebellar and cortical
- Microglial differentiation and immunological assays
- Microscopy (live cell, fluorescence, confocal)
- Functional assays for neural activity (calcium transients)
- Single cell sequencing and transcriptomic analysis
- DNA repair and basic radiation biology
Area of Interest
- Stem cell biology, pluripotency
- Developmental biology
- Cellular neuroscience, focusing on identification of therapeutic strategies to reverse or halt neurological disease
- Neuroinflammation and cell-cell crosstalk
- Genome protection
- Metabolomics
- Drug/therapy development (including novel viral agents for gene therapy, as well as small-molecule and metabolite-based therapies).
Professional Associations
Australian Neuroscience Society (ANS)
Funding
- MRFF
- Action for A-T project grant
Publications
Adams RC, Carter-Cusack D, Llanes GT, Hunter CR, Vinnakota JM, Ruitenberg MJ, Vukovic J, Bertolino P, Chand KK, Wixey JA, Nayler SP, Hill GR, Furlan SN, Zeiser R, MacDonald KPA. CSF1R inhibition promotes neuroinflammation and behavioral deficits during graft-versus-host disease in mice. Blood. 2024 Mar 7;143(10):912-929. doi: 10.1182/blood.2023022040. PMID: 38048572.
Krycer JR, Nayler SP. A Survey of the Metabolic Landscape of the Developing Cerebellum at Single-Cell Resolution. Cerebellum. 2022 21(5):838-850. doi: 10.1007/s12311-022-01415-2. PMID: 35767214.
Nayler SP, Agarwal D, Curion F, Bowden R, Becker EBE. High-resolution transcriptional landscape of xeno-free human induced pluripotent stem cell-derived cerebellar organoids. Sci Rep. 2021 11(1):12959. doi: 10.1038/s41598-021-91846-4. PMID: 34155230.