Background
This theme examines how senescent cells drive chronic kidney disease (CKD) progression and frailty.
Ongoing work includes:
- Single-cell omics: Mapping senescent cell states and immune microenvironments in human CKD using single-cell RNA-Seq, spatial transcriptomics, and proteomics and wet lab validation.
- Future work: Therapeutic translation: Evaluation of senolytic agents such as fisetin and navitoclax in ex vivo human kidney tissue and clinical trial settings (SUSTAIN-CKD).
- Developing senescence “fingerprints” across organs and disease states using publicly available and in-house datasets.
- Comparative analyses of multiorgan single-cell data to identify conserved and tissue-specific ageing mechanisms.
For Students
Other Student Projects
Fuelling the fight—How diet shapes the immune response to leukaemia background
Discovering novel immunoregulatory molecules underlying the pathogenesis of systemic lupus erythematosus.
Investigating the role of purinergic receptor signalling in the onset and progression of systemic lupus erythematosus